Tamoxifen retinopathy.
نویسندگان
چکیده
A 63-year-old female on long-term, high-dose tamoxifen treatment for metastatic breast cancer developed bilateral intraretinal refractile opacities, lesions at the level of the retinal pigment epithelium, and cystoid macular oedema.
منابع مشابه
A case of tamoxifen keratopathy.
Tamoxifen citrate (ICI46474) is an antiestrogenic agent used in cases of disseminated breast carcinomas and as adjuvant postoperative therapy. Toxic reactions to tamoxifen, such as decreased visual acuity, bilateral macular edema, and yellow-white dots in the paramacular and foveal areas, are relatively rare (reported incidence between 0.9%-12%). In 1978, Kaiser-Kupfer and Lippman first reporte...
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PURPOSE To present a case of tamoxifen retinopathy on a 57-year-old woman. DESIGN An observational case. METHODS A review of history, clinical examination, and findings on Spectral-domain Optical Coherence Tomography (SD-OCT), fluorescein angiogram (FA) and electro-oculogram (EOG) was conducted. RESULTS A 57-year old female patient, who had been treated with oral tamoxifen after mastectom...
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PURPOSE Differential diagnosis of maculopathies can be difficult but is important if patients also suffer from other diseases such as breast cancer treated with antiestrogens. The main possible diagnoses, especially in the elderly, are age-related macular degeneration, tamoxifen and cancer-associated retinopathy (CAR). METHODS We describe an 84-year-old patient with breast and colon cancer, w...
متن کاملPeripheral retinopathy and maculopathy in high-dose tamoxifen therapy.
PURPOSE To describe the clinical, angiographic, and optical coherence tomography (OCT) features of high-dose tamoxifen retinopathy in three male patients. DESIGN Observational case series. METHODS A review of history, clinical examination, and findings on fluorescein angiography (FA) and optical coherence tomography (OCT) was conducted. RESULTS Three male patients receiving high-dose tamo...
متن کاملImaging tamoxifen retinopathy using spectral-domain optical coherence tomography
A case of tamoxifen retinopathy examined with spectral-domain optical coherence tomography (SD-OCT) is presented. The typical refractile deposits are located between ganglion cell layer and inner plexiform layer in SD-OCT. A defect on the outer retinal layer with disruption of the photoreceptor layer with sharp edges is seen. The still attached posterior hyaloids gives evidence of other pathome...
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 65 3 شماره
صفحات -
تاریخ انتشار 1981